发明名称 |
PARENTERAL FORMULATIONS OF GEMCITABINE DERIVATIVES |
摘要 |
The present invention relates to parenteral formulations for certain long chain saturated and monounsaturated fatty acid derivatives of 2',2'-difluorodeoxycytidine (Gemcitabine). In particular, the present invention relates to a parenteral pharmaceutical composition and a method of the preparation thereof, in order to accommodate therapeutically effective doses of the said derivatives ameliorating compliance in the treatment of cancer. The composition has an average particle size in the range of 2.5-30 nm and typically contains a phospholipid. A preferred active ingredient is gemcitabine-5'-elaidic acid ester.
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申请公布号 |
CA2778432(A1) |
申请公布日期 |
2011.05.26 |
申请号 |
CA20102778432 |
申请日期 |
2010.11.15 |
申请人 |
CLAVIS PHARMA ASA |
发明人 |
AHRABI, SAYEH;MYHREN, FINN;ERIKSEN, OLE HENRIK |
分类号 |
A61K9/127;A61K9/133;A61K31/7068;A61P35/00;C07H19/06 |
主分类号 |
A61K9/127 |
代理机构 |
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