METHODS FOR PREPARING STATIN COMPOUNDS BY LACTONIZATION

摘要

Methods for preparing statin compounds by lactonization are disclosed, which comprise the following step: lactonizing compounds of formula II into compounds of formula I in the presence of strong acid catalyst and dehydrator in the first solvent, wherein Z is H, ammonium, metal cations; R1 is H or C1-6alkyl, H or CH3 is prefered; R2 is CH3, OH, CH2OH, CH2OC(O)R3, CH2OR3 or COOR4, CH3 or OH is prefered; R3 or R4 is independently selected from H or C1-6alkyl.