Production of galactosylated glycoproteins in lower eukaryotes

摘要

The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal beta-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein.