发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Nav1.8 GENE |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene in a cell.
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申请公布号 |
US2011124711(A1) |
申请公布日期 |
2011.05.26 |
申请号 |
US201113016896 |
申请日期 |
2011.01.28 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
SAH DINAH;FRANK-KAMENETSKY MARIA;GEICK ANKE;HADWIGER PHILIPP;ROEHL INGO;TAN PAMELA;VORNLOCHER HANS-PETER |
分类号 |
A61K31/713;A61P29/00;C07H21/02;C12N5/00;C12N5/02;C12N5/10;C12N15/113;C12N15/63 |
主分类号 |
A61K31/713 |
代理机构 |
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主权项 |
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地址 |
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