发明名称 |
PROCESS FOR PRODUCTION OF W/O/W EMULSION, PROCESS FOR PRODUCTION OF LIPOSOME EMPLOYING THE PROCESS, AND POROUS MEMBRANE FOR USE IN THE METHODS |
摘要 |
Disclosed is a liposome production process which enables the production of a liposome that has a nano-size particle diameter and a high water-soluble drug encapsulation rate. Specifically disclosed is a process for producing a W1/O/W2 emulsion, which is characterized by comprising the steps of (1) emulsifying an organic solvent (O) that is a volatile organic solvent, an aqueous solvent (W1) and a mixed lipid component (F1) to prepare a W1/O emulsion and (2) dispersing the W1/O emulsion produced in step (1) in an aqueous solvent (W2) using a porous membrane to prepare a W1/O/W2 emulsion, wherein the surface of the porous membrane has been treated with a hydrophilic component so that the surface has a water contact angle of 0 to 42° inclusive in the air. |
申请公布号 |
WO2011062132(A1) |
申请公布日期 |
2011.05.26 |
申请号 |
WO2010JP70274 |
申请日期 |
2010.11.15 |
申请人 |
KONICA MINOLTA HOLDINGS, INC.;ISODA, TAKESHI;MOTOKUI, YASUYUKI;WADA, TAKESHI |
发明人 |
ISODA, TAKESHI;MOTOKUI, YASUYUKI;WADA, TAKESHI |
分类号 |
A61K9/113;A61K47/44;B01J13/00 |
主分类号 |
A61K9/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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