MODIFIED ADENOVIRUS CONTAINING A STABILIZED ANTIBODY

摘要

The present invention relates generally to the fields of vector biology and gene therapy. The invention is based, in part, on Applicants' discovery that stabilization of the targeting molecule results in successful incorporation of antibody-related molecules into the adenovirus capsid. Accordingly, the present invention relates to the production of recombinant adenoviral vectors containing stabilized antibodies for cell-specific targeting.