发明名称 |
BIOSYNTHETIC SYSTEM THAT PRODUCES IMMUNOGENIC POLYSACCHARIDES IN PROKARYOTIC CELLS |
摘要 |
The invention is directed to bioconjugate vaccines comprising N-glycosylated proteins. Further, the present invention is directed to a recombinant prokaryotic biosynthetic system comprising nucleic acids encoding an epimerase that synthesizes an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus. The invention is further directed to N-glycosylated proteins containing an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus and an expression system and methods for producing such N-glycosylated proteins. |
申请公布号 |
CA2780487(A1) |
申请公布日期 |
2011.05.26 |
申请号 |
CA20102780487 |
申请日期 |
2010.11.16 |
申请人 |
GLYCOVAXYN AG |
发明人 |
WACKER, MICHAEL;WAECHTER, CHARLES |
分类号 |
C07K9/00;A61K39/104;A61K39/112;A61K39/116;A61K39/385;A61P31/04;A61P37/04;C07K14/195;C07K14/21;C07K14/245;C07K14/25;C12N1/21;C12N15/31;C12N15/63;C12P15/00;C12P21/00 |
主分类号 |
C07K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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