OIL-IN-WATER ADJUVANTED INFLUENZA VACCINE

摘要

The present invention is related to the use of a composition comprising at least one antigen derived from a H5 influenza virus strain, for the preparation of an influenza immunization composition for administration according to a regimen comprising at least a 1st and a 2nd administration steps timely separated, wherein the H5 influenza virus strain of the 1st administration step is different from the H5 influenza virus strain of the 2nd administration step and wherein the immunization composition used in at least one of the 1st or the 2 nd administration step comprises an oil-in-water emulsion as an adjuvant, wherein said oil-in-water emulsion comprises at least squalene, an aqueous solvent, a polyoxyethylene alkyl ether hydrophilic nonionic surfactant, a hydrophobic nonionic surfactant, and wherein said oil-in-water emulsion is obtainable by a phase inversion temperature process and wherein 90 % of the population by volume of the oil drops has a size less than 200 nm, and optionally less than 150 nm.