| 摘要 |
Local active substance delivery system, comprises spherical or rotational symmetric bodies, which are formed of polymethylmethacrylate or polymethyl methacrylate co-methylacrylate, zirconium dioxide or barium sulfate and one or more active substance, preferably antibiotics, where the local active substance are formed by radical polymerization activator or residues of these polymerization activators at 10-80[deg]C, and the activator does not comprised of aromatic amines, heavy metal salts and barbiturates. An independent claim is included for the preparation of the local active substance comprising preparing a paste by mixing of methyl methacrylate, polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxide and/or barium sulfate or more active substances and a thermally decaying free radical initiator, where the paste possesses a viscosity that it cannot be deformed at ambient temperature by the effect of the gravity; spraying the paste with an injection molding device without the application of heat at ambient temperature to form spherical or rotationally symmetric bodies, which are sprayed on a filament; and heating the bodies up to a temperature, at which the polymerization initiator decays. ACTIVITY : Antibacterial; Antiinflammatory; Osteopathic. MECHANISM OF ACTION : None given. |
