发明名称 |
BIODEGRADABLE TRIBLOCK COPOLYMERS, SYNTHESIS METHODS THEREFOR, AND HYDROGELS AND BIOMATERIALS MADE THERE FROM |
摘要 |
A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent intimately contained within the hydrogel. In one preferred embodiment of the invention, the A polymer block 10 is poly(ethylene oxide) (PEO) and the B polymer block is poly[(R)-3-hydroxybutyrate] (PHB), and the copolymer is the triblock ABA copolymer PEO-PHB-PEO. A method of synthesizing the amphiphilic triblock copolymer is also provided.
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申请公布号 |
CA2490007(C) |
申请公布日期 |
2011.05.24 |
申请号 |
CA20032490007 |
申请日期 |
2003.07.18 |
申请人 |
OMEROS CORPORATION;INSTITUTE OF MATERIALS RESEARCH AND ENGINEERING |
发明人 |
LI, JUN;LI, XU;NI, XIPING;LEONG, KAM W. |
分类号 |
C08G81/02;A61F2/00;A61K9/00;A61K9/06;A61K9/107;A61K9/51;A61K47/32;A61K47/34;A61K47/40;A61K47/48;A61L27/34;A61L27/52;A61L27/54;A61L31/08;A61L31/10;A61L31/14;A61L31/16 |
主分类号 |
C08G81/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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