发明名称 |
A PHARMACEUTICAL TABLET SYSTEM THAT FLOATS ON GASTRIC FLUID FOR MULTIPULSE RELEASE OF ACTIVE SUBSTANCE, AND RESPECTIVE PROCESSES OF PRODUCING SAME AND A CUP-SHAPED ENVELOPE OF SAME |
摘要 |
A tablet system for prolonged floating in or on gastric fluid for releasing therein pharmaceutically active substances in an alternate succession of substance release and no-release periods is made up of a multilayered core placed in a cup-shaped envelope. The core is made up of release layers and no-release layers devoid of pharmaceutically active substance, superposed in alternate succession. The cup-shaped envelope covers bottom and side surfaces of the core while leaving exposed an upper surface of the core. The cup-shaped envelope provides for buoyancy by being formed of a compression-sintered mixture comprising hydrophobic material and inert powdered filler. The hydrophobic material is composed of fatty and/or waxy material capable of being sintered by compression and whose bulk density is lower than gastric fluid density. The powdered filler has a loose powder density that is lower than gastric fluid density.
|
申请公布号 |
CA2441123(C) |
申请公布日期 |
2011.05.24 |
申请号 |
CA20022441123 |
申请日期 |
2002.03.18 |
申请人 |
JAGOTEC AG |
发明人 |
GRENIER, PASCAL;QUINTON, JACQUES;RICCHI, ELISABETH;VERGNAULT, GUY |
分类号 |
A61K9/20;A61K9/22;A61K9/00 |
主分类号 |
A61K9/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|