发明名称 Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators
摘要 The invention relates to pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2 and Y3 independently are e.g. CR10, NH, S or O, whereby at least one of Y1, Y2 and Y3 represents CR10; R1 represents chloro or bromo; R2, R3, R4, R5, R6 and R7 represent e.g. hydrogen or C1-C6-alkyl, and R10 represents e.g. hydrogen, halogen or phenyl; which are potent mGluR5 modulators and are e.g. useful for the treatment of various neurological disorders.
申请公布号 US7947689(B2) 申请公布日期 2011.05.24
申请号 US20070890211 申请日期 2007.08.03
申请人 MERZ PHARMA GMBH & CO. KGAA 发明人 DANYSZ WOJCIECH;DEKUNDY ANDRZEJ;HECHENBERGER MIRKO;HENRICH MARKUS;JATZKE CLAUDIA;NAGEL JENS;PARSONS CHRISTOPHER GRAHAM RAPHAEL;WEIL TANJA;FOTINS JURIS;GUTCAITS ALEKSANDRS;KALVINSH IVARS;ZEMRIBO RONALDS;KAUSS VALERJANS
分类号 C07D487/04;A61K31/519;A61P25/02;A61P25/22;A61P25/28;A61P35/00 主分类号 C07D487/04
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