发明名称 |
TARGETING AND PROLONGING ASSOCIATION OF DRUGS TO THE LUMINAL SURFACE OF THE PULMONARY VASCULAR ENDOTHELIAL CELLS |
摘要 |
Methods for targeting and prolonging association of a selected drug to the luminal surface of pulmonary vascular endothelium of an animal are provided wherein a selected drug is administered to an animal in combination with a non-internalizable antibody which binds to an antigen on the luminal surface of the pulmonary vasculature. This method is particularly useful in dissolution of fibrin clots or prevention of the intravascular coagulation in the pulmonary vasculature.
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申请公布号 |
CA2339487(C) |
申请公布日期 |
2011.05.24 |
申请号 |
CA19992339487 |
申请日期 |
1999.08.02 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;LOUISIANA STATE UNIVERSITY AGRICULTURAL AND MECHANICAL COLLEGE |
发明人 |
MUZYKANTOV, VLADIMIR R.;MURCIANO, JUAN CARLOS;GRANGER, D. NEIL |
分类号 |
A61K39/395;A61K47/48;A61K51/10;A61P7/02 |
主分类号 |
A61K39/395 |
代理机构 |
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