发明名称 |
SOLID FORMULATION WITH IMPROVED SOLUBILITY AND STABILITY AND METHOD FOR PRODUCING SAID FORMULATION |
摘要 |
The present invention relates to a solid formulation with improved solubility and maintained stability including a chemical substance poorly soluble in water as a pharmaceutically active ingredient formulated in an improved manner. More specifically, the present invention relates to a solid formulation having improved water-solubility which comprises a chemical substance poorly soluble in water as a pharmaceutically active ingredient, a water-soluble polymer substance and an inorganic porous substance, characterized in that (1) the chemical substance poorly soluble in water forms a solid dispersion together with the water-soluble polymer substance, (2) the water-soluble polymer substance forming the solid dispersion is in the form of fine pieces, and (3) the water-soluble polymer substance is in the form of fine pieces is maintained to be adsorbed on and/or adhered to the surface of the inorganic porous substance. The solid formulation can be produced by stirring and mixing a solution obtained by dissolving a chemical substance poorly soluble in water as a pharmaceutically active ingredient and a water-soluble polymer substance in an organic solvent with an inorganic porous substance and then granulating and drying the mixture.
|
申请公布号 |
CA2582767(C) |
申请公布日期 |
2011.05.24 |
申请号 |
CA20052582767 |
申请日期 |
2005.10.20 |
申请人 |
JAPAN TOBACCO INC. |
发明人 |
YAMANE, SHOGO;YAMANE, HIROFUMI;SUNAMI, MASAKI |
分类号 |
A61K47/38;A61K9/10;A61K9/14;A61K45/00;A61K47/02;A61K47/04;A61K47/30;A61K47/32;A61P3/06 |
主分类号 |
A61K47/38 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|