OLIGONUCLEOTIDE COMPOSITIONS AND THEIR USE FOR THE MODULATION OF IMMUNE RESPONSES

摘要

The present invention relates to 3'-OH, 5'-OH polynucleotide sequence compositions and methods for activating an immune response in an individual, and more preferably, for activating r antigen presenting cells in the individual. In one embodiment, the antigen presenting cell is a dendritic cell. The present invention also includes compositions and methods for activating dendritic cells in vitro. These dendritic cells may then be administered to an individual. Preferred 3'-OH, 5'-OH polynucleotide sequences comprise six bases wherein at least 50% of the bases are guanine and the 5' base is guanine. The compositions may comprise a phosphodiester or phosphorothioate backbone.