发明名称 |
Peg-uratoxidase-konjugater og anvendelse deraf |
摘要 |
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. <IMAGE> |
申请公布号 |
DK1588716(T3) |
申请公布日期 |
2011.05.23 |
申请号 |
DK20050011069T |
申请日期 |
1999.08.02 |
申请人 |
MOUNTAIN VIEW PHARMACEUTICALS, INC.;DUKE UNIVERSITY |
发明人 |
KELLY, SUSAN J.;HERSHFIELD, MICHAEL S.;L. DAVID WILLIAMS;SAIFER, MARK G. P.;SHERMAN, MERRY R. |
分类号 |
A61K47/48;A61K38/00;A61K38/44;C12N1/21;C12N9/02;C12N9/06;C12N9/96 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|