SOME SUBSTITUTED AMIDES, METHOD OF THEIR OBTAINING AND METHOD OF THEIR APPLICATION

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to compound of formula 2: and to its pharmaceutically acceptable salts and their mixtures, where values of R, M, Q, Z, W, D radicals are described in i.1 of the invention formula. Invention also relates to pharmaceutical compositions, which possess inhibiting activity with respect to Btk, based on formula 2 compounds. ^ EFFECT: obtained are novel compounds and based on them pharmaceutical compositions which can be applied in medicine for treatment of patients with diseases associated with inhibiting Btk activity and/or B-cell activity. ^ 55 cl, 19 ex