发明名称 |
Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone |
摘要 |
<p>A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.</p> |
申请公布号 |
AU2005320001(B2) |
申请公布日期 |
2011.05.19 |
申请号 |
AU20050320001 |
申请日期 |
2005.12.22 |
申请人 |
THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OFOSAKA UNIVERSITY |
发明人 |
ISAO FUKE;TOSHIYUKI ONISHI;TAKESHI NABESHIMA;MICHIAKI TAKAHASHI;MASAHIDE ISHIBASHI;TOYOKAZU ISHIKAWA;KOUICHI MORITA;SHINICHI MIYAKE;HIDEO GODA |
分类号 |
C12N15/09;A61K39/12;A61K39/295;A61P31/12;C12N7/00;C12N7/04 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|