发明名称 |
Compositions and Methods for Inhibiting Expression of TGF-BETA Receptor Genes |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a TGF-beta receptor type I gene, comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length and which is substantially complementary to at least a part of a TGF-beta receptor type I gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a TGF-beta receptor type I gene using said pharmaceutical composition; and methods for inhibiting the expression of a TGF-beta receptor type I gene in a cell.
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申请公布号 |
US2011119781(A1) |
申请公布日期 |
2011.05.19 |
申请号 |
US200913054111 |
申请日期 |
2009.07.08 |
申请人 |
BRAMLAGE BIRGIT;HOSSBACH MARKUS;TAN PAMELA;VAMLOCHER HANS-PETER |
发明人 |
BRAMLAGE BIRGIT;HOSSBACH MARKUS;TAN PAMELA;VAMLOCHER HANS-PETER |
分类号 |
A01K67/027;C07H21/02;C12N5/10;C12N15/113 |
主分类号 |
A01K67/027 |
代理机构 |
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