COMPOSITIONS AND METHODS FOR WOUND TREATMENT

摘要

Provided herein are compositions, methods, systems, and kits for wound healing. As shown herein, CCN2/CTGF stimulated mesenchymal progenitor cells can form aSMA- fibroblasts. Further, TGF was shown to stimulate further differentiation of aSMA- fibroblasts to myofibroblasts associated with fibrosis. One aspect provides a composition including CCN2/CTGF and a TGF inhibitor, a P38 inhibitor, or a tyrosine kinase inhibitor. Another aspect provides a method of treating tissue wounds with CCN2/CTGF-containing compositions. Also provided are systems and kits for wound healing. Also provided are methods for forming aSMA- fibroblasts mesenchymal progenitor cells.