发明名称 |
COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS |
摘要 |
A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a ceramide-increasing retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) compounds selected from the groups consisting of (i) a non-18 carbon chain length L-threo-sphinganine(s) or pharmaceuticeutically acceptable salt thereof, (ii) glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor(s), and (iii) sphingomyelin or dihydrosphingomyelin synthase inhibitor(s). Preferred L-threo-sphinganines are of carbon chain length 17 carbons, 19 carbons and 20 carbons. A preferred glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred sphingomyelin or dihydrosphingomyelin synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred hyperproliferative disorder is brain cancers. |
申请公布号 |
WO2011060332(A2) |
申请公布日期 |
2011.05.19 |
申请号 |
WO2010US56626 |
申请日期 |
2010.11.12 |
申请人 |
TEXAS TECH UNIVERSITY;MAURER, BARRY, JAMES;REYNOLDS, CHARLES, PATRICK |
发明人 |
MAURER, BARRY, JAMES;REYNOLDS, CHARLES, PATRICK |
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