PREPARATION METHOD OF LACTATE POLYMERS AND LACTATE COPOLYMERS USING POLYHYDROXYALKANOATE SYNTHASE MUTANTS

摘要

The present invention relates to diverse polyhydroxyalkanoate synthase (PHA synthase) mutants capable of synthesizing lactate polymers (PLAs) and lactate copolymers (PLA copolymers), and a preparation method of the lactate polymers and copolymers using the PHA synthase mutants. More specifically, the present invention relates to polyhydroxyalkanoate synthase mutants having SEQ. ID. NO. 2, 4, 6 or 8; and a preparation method of PLA polymers and PLA copolymers using the synthase mutants. According to the present invention, polyhydroxyalkanoate synthase mutants having SEQ. ID. NO. 2, 4, 6 or 8 can have PLA polymer and copolymer synthase activity by the variation in amino acid sequence that affects the PLA polymer synthase activity. Further, the use of such synthase mutants makes it possible to prepare PLA polymers and copolymers having different properties from each other.