| 摘要 |
This invention describes a microengineered SFC system for rapidly and efficiently separating the constituents of a complex mixture. The SFC system includes a microchannel that is microfabricated from a suitable substrate so that it forms a chromatographic column for separation of chemicals. The surface area of the microchannel of the column is sufficiently small as to permit use of miniature and relatively inexpensive pumps, and the thermal mass of the microengineered column is sufficiently low as to permit rapid temperature cycling using a miniature, low power and inexpensive heating element. At least a portion of this microchannel is packed with suitable sorbent materials or includes surfaces which are suitably coated with sorbent, or both, so as to retain and elute analyte under certain conditions. As a result analyte passing within this microchannel undergoes chromatographic separation.
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