DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUID WITH STERILIZING RADIATION

摘要

PROBLEM TO BE SOLVED: To provide a continuous flow device and method that are highly effective in uniformly irradiating high optical density fluids having low radiation penetrations.

SOLUTION: There are provided the device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device 10 comprises a radiation permeable cylindrical tube 12 having a concentric cylindrical rotor disposed therein, thereby providing a thin gap 16 therebetween. A top plate 18 having a fluid outlet 26 and a bottom plate 20 having a fluid inlet 24 seal the cylindrical tube 12. The inlet 24 and outlet 26 are both in fluid communication with the thin gap. A rotor shaft 36 is disposed axially through the cylindrical rotor 14 and is connected to a motor 30.

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