CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1.

摘要

This invention relates to novel compounds of the Formula Ik, Im¹, Im², Im⁵, In¹, In², In⁵, lo¹, lo², lo⁵, Ip¹, Ip³, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.