(POLY)-GLYCEROLPHOSPHATE-BASED ANTI-GRAM POSITIVE BACTERIAL VACCINE

摘要

The invention provides an immunogenic composition comprising polyglycerol phosphate (PGP) for the treatment and/or prevention of staphylococcal infection. In some embodiments, the PGP is conjugated to a T-cell dependent antigen. The invention also provides methods for using the compositions of the invention for treating and/or preventing staphylococcal infections. The invention also provides methods for synthesizing PGP. The invention also provides methods for conjugating PGP to a T-cell dependent antigen.