发明名称 |
COMPOSITIONS COMPRISING MG29 NUCLEIC ACIDS, POLYPEPTIDES AND ASSOCIATED METHODS OF USE |
摘要 |
<p>Disclosed herein are compositions and methods for treatment of muscle dysfunction (including sarcopenia) and other diseases involving skeletal muscle, including age-related muscle dysfunction. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal muscle disorder, including those related to thr normal aging process. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ regulation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.</p> |
申请公布号 |
EP2320931(A2) |
申请公布日期 |
2011.05.18 |
申请号 |
EP20090798748 |
申请日期 |
2009.07.16 |
申请人 |
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
MA, JIANJIE;WEISLEDER, NOAH |
分类号 |
A61K38/17;A01K67/027;A61K48/00;A61P21/00;C07K14/705;C12N15/85 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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