Inhibitors of centrosomal clustering

摘要

The present invention is concerned with compounds modulating the function of a target gene in a cell, wherein the target gene is selected from the list consisting of CEP164, ARL2, HEI-C, SPC24, CENP-T, MKLP1, HIST1H2BO, HIST1H2BJ, FAM29A, ADPGK, ARSF, MAP6, GOLM1, STX5A, CACNA1F, TXNL1, USP54, RGL2, MAP4K5, TULP3, GRP137, ZNF354C, MEPCE, MTF2, TNRC4, POP1, SF3B1, SNRPD2, UPF3A, EIF3S6IP, ZNF17, NACAD, C4ORF15, C1ORF114, C19ORF52, ABHD8, TM4SF18, F8A1, KIAA1191, C20ORF149, and C110RF4. Also proposed is a medicament comprising said compound for the treatment or prevention of cancer. Furthermore, the use of said compound for the manufacture of a medicament for the treatment and / or prevention of cancer is proposed as well as methods for the identification of a compound capable of inhibiting ccntrosomal clustering, for the identification of a compound capable of binding to a polypeptide encoded by one of said target genes, and for the identification of cancer cells in a sample.