发明名称 |
Method of manufacture of 1,3-dioxolane and 1,3-oxathiolane nucleosides |
摘要 |
<p>Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.</p> |
申请公布号 |
EP2322518(A1) |
申请公布日期 |
2011.05.18 |
申请号 |
EP20100181678 |
申请日期 |
1999.08.12 |
申请人 |
GILEAD SCIENCES, INC.;EMORY UNIVERSITY |
发明人 |
CLEARY, DARRYL;SORIA, JOSE;PAINTER, GEORGE R.;LIOTTA, DENNIS C.;ALMOND, MERRICK;SZNAIDMAN, MARCOS L. |
分类号 |
C07D327/04;A61K31/505;C07D319/06;C07D411/04;C07D473/00 |
主分类号 |
C07D327/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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