发明名称 |
4-OXOQUINOLINE COMPOUND AND USE THEREOF AS HIV INTEGRASE INHIBITOR |
摘要 |
<p>An anti-HIV agent containing, as an active ingredient, a 4-oxoquinoline compound represented by the following formula [I] (see formula I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.</p> |
申请公布号 |
CA2470365(C) |
申请公布日期 |
2011.05.17 |
申请号 |
CA20032470365 |
申请日期 |
2003.11.20 |
申请人 |
JAPAN TOBACCO INC. |
发明人 |
SATOH, MOTOHIDE;KAWAKAMI, HIROSHI;ITOH, YOSHIHARU;SHINKAI, HISASHI;MOTOMURA, TAKAHISA;ARAMAKI, HISATERU;MATSUZAKI, YUJI;WATANABE, WATARU;WAMAKI, SHUICHI |
分类号 |
C07D215/56;A61K31/4375;A61K31/47;A61K31/4709;A61K31/5377;A61K45/06;A61P31/12;A61P31/18;A61P43/00;C07D215/58;C07D401/06;C07D409/06;C07D417/06;C07D471/04 |
主分类号 |
C07D215/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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