发明名称 |
siRNA microbicides for preventing and treating diseases |
摘要 |
The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in an essential gene of a virus. The virus may be a herpesvirus, for example, HSV-1 or HSV-2. Preferably, the herpesvirus is HSV-2. The microbicidal composition further comprises a pharmaceutically acceptable carrier. Also included in the invention are methods to prevent and treat viral infections by administration of the microbicidal composition. Preferably, the microbicidal composition is administered transmucosally.
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申请公布号 |
US7943589(B2) |
申请公布日期 |
2011.05.17 |
申请号 |
US20060916334 |
申请日期 |
2006.06.05 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;IMMUNE DISEASE INSTITUTE, INC. |
发明人 |
LIEBERMAN JUDY;PALLISER DEBORAH;KNIPE DAVID |
分类号 |
A61K31/70;C07H21/02;C07H21/04;C12N15/113;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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