发明名称 |
SUBSTITUTED 1-PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
摘要 |
The invention concerns 1-substitued piperazinylacylpiperidine derivatives of general formula (I) (see formula I) wherein: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom, a trifluoromethyl radical, C1-C4 alkyl, a C1-C4 alkoxy, a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom, an -OR5 group, a -CH2OR5 group, a -NR6R7 group; a -NR8COR9 group; a -NR8CONR10R11 group; a -CH2NR12R13 group; a -CH2NR8CONR14R15 group; a C1-C4 alkoxycarbonyl; a -CONR16R17 group; or R3 forms a double bond between the carbon atom whereto it is bound and the neighbouring carbon atom of the piperidine cycle; R4 represents an aromatic group selected among (see formula II); (see formula III); (see formula IV); (see formula V); (see formula VI); (see formula VII); said aromatic groups being unsubstituted, monosubstituted or disubstituted by a substituent selected independently among a halogen atom, a C1-C4 alkyl, a C1-C4 alkoxy, a trifluoromethly radical. The invention also concerns a method for preparing said compounds and their therapeutic use.
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申请公布号 |
CA2487840(C) |
申请公布日期 |
2011.05.17 |
申请号 |
CA20032487840 |
申请日期 |
2003.06.05 |
申请人 |
SANOFI-AVENTIS |
发明人 |
BONO, FRANCOISE;BOSCH, MICHAEEL;DOS SANTOS, VICTOR;HERBERT, JEAN MARC;NISATO, DINO;TONNERRE, BERNARD;WAGNON, JEAN |
分类号 |
C07D401/12;C07D417/14;A61K31/496;A61K31/497;A61K31/506;A61P3/10;A61P9/00;A61P9/04;A61P9/10;A61P17/02;A61P17/14;A61P19/00;A61P19/02;A61P19/10;A61P25/00;A61P25/02;A61P25/04;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/28;A61P27/00;A61P27/02;A61P29/00;A61P35/00;A61P35/02;A61P35/04;A61P37/00;A61P43/00;C07D401/14;C07D417/12 |
主分类号 |
C07D401/12 |
代理机构 |
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地址 |
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