发明名称 |
METHOD FOR PRODUCING MASS-CODED COMBINATORIAL LIBRARIES |
摘要 |
The present invention provides a method for producing a mass-coded combinatorial library comprising a set of compounds having the general formula X(Y)n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1. The method comprises selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 50 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90 % of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. The method further comprises contacting the peripheral moiety precursor subset with a scaffold precursor which has n reactive groups. Methods of use of the mass-coded combinatorial library produced by this method for identifying a ligand to a particular biomolecule are also disclosed. |
申请公布号 |
CA2313957(C) |
申请公布日期 |
2011.05.17 |
申请号 |
CA20002313957 |
申请日期 |
2000.07.14 |
申请人 |
NEOGENESIS, INC. |
发明人 |
NASH, HUW M.;BIRNBAUM, SETH;WINTNER, EDWARD A.;KALGHATGI, KRISHNA;SHIPPS, GERALD;JINDAL, SATISH |
分类号 |
G01N37/00;B01J19/00;C07B61/00;C07H21/00;C40B30/04;C40B40/06;C40B60/00;C40B70/00 |
主分类号 |
G01N37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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