In certain aspects, the present invention provides compositions and methods for treating fatty liver disease by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies and anti-activin A or B antibodies. A variety of hepatic and metabolic disorders may be improved by treating fatty liver disease.
申请公布号
WO2011056896(A1)
申请公布日期
2011.05.12
申请号
WO2010US55331
申请日期
2010.11.03
申请人
ACCELERON PHARMA INC.;KONCAREVIC, ALAN;LACHEY, JENNIFER;SEEHRA, JASBIR;SHERMAN, MATTHEW, L.
发明人
KONCAREVIC, ALAN;LACHEY, JENNIFER;SEEHRA, JASBIR;SHERMAN, MATTHEW, L.