DERIVATIVES OF 5,6,7,8-TETRAHYDROINDOLIZINE INHIBITING HSP90, COMPOSITIONS CONTAINING SAME, AND USE THEREOF

摘要

The invention relates to the novel materials of formula (I), Het and Het' being an aromatic or partially unsaturated, dihydro or tetrahydro, mono- or bicyclic heterocyclic compound having 5 to 11 members, containing 1 to 4 heteroatoms, selected from among N, O or S, optionally substituted by one or more identical or different radicals R1 or R'1 such as expressed below, X being NH-CO or CO-NH, R1 and/or R'1 belonging to the group consisting of H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, free carboxy or carboxy esterified by an alkyl radical, carboxamide, CO-NH(alkyl), CON(alkyl)2, NH-CO-alkyl, sulphonamide, NH-SO2-alkyl, S(O)2-NH-alkyl or S(O2)-N(alkyl)2, all the alkyl, alkoxy and alkylthio radicals in turn being optionally substituted by one or more identical or different radicals selected from among halogen, hydroxy, alkoxy, amino, alkylamino and dialkylamino, wherein said materials are in any isomer and salt form and used as drugs.