发明名称 |
METHODS OF GENERATING IMPROVED ANTIGEN-BINDING AGENTS USING CHAIN SHUFFLING AND OPTIONALLY SOMATIC HYPERMUTATION |
摘要 |
<p>The invention relates to a method of identifying a desired antigen-binding agent that binds to an antigen of interest. The method utilizes a combinatorial approach wherein a nucleic acid sequence encoding a polypeptide comprising a first component of an antigen-binding agent is provided to a population of cells together with a library of nucleic acid sequences, each of which encodes a polypeptide comprising a second component of an antigen-binding agent. The method further comprises subjecting one or more of the nucleic acid sequences encoding a first component, a second component, and/or an identified antigen-binding agent to somatic hypermutation.</p> |
申请公布号 |
WO2011056864(A1) |
申请公布日期 |
2011.05.12 |
申请号 |
WO2010US55290 |
申请日期 |
2010.11.03 |
申请人 |
ANAPTYSBIO, INC.;HORLICK, ROBERT |
发明人 |
HORLICK, ROBERT |
分类号 |
C12P21/06;C12P21/04;C40B30/04;C40B40/02 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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