| 发明名称 |
METHOD FOR PRODUCING ANTIBODY COMPOSITION |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for producing an antibody composition using host cells producing the antibody composition capable of controlling the sugar structure of antibody molecules. <P>SOLUTION: The method for producing an antibody composition such as a fused protein having the Fc domain of an antibody having high antibody-dependent cellular cytotoxic activity useful for various diseases is provided. The antibody composition is one that has ≥20% ratio of sugar chains free from fucose bonded to N-acetylglucosamine at the sugar chain reducing end over the total N-glycoside linkage complex sugar chains bonded to the Fc domain. <P>COPYRIGHT: (C)2011,JPO&INPIT |
| 申请公布号 |
JP2011092203(A) |
申请公布日期 |
2011.05.12 |
| 申请号 |
JP20100290576 |
申请日期 |
2010.12.27 |
| 申请人 |
KYOWA HAKKO KIRIN CO LTD |
发明人 |
KANDA YUTAKA;SATO MITSUO;NAKAMURA KAZUYASU;UCHIDA KAZUHISA;SHINKAWA TOYOHIDE;YAMANE NAOKO;HOSAKA EMI;YAMANO KAZUYA;YAMAZAKI MOTOO;HANAI NOBUO |
| 分类号 |
C12P21/08;A61K39/395;C07K16/00;C07K16/06;C07K16/18;C07K16/28;C07K16/32;C12N5/10;C12N9/04;C12N9/10;C12N9/12;C12N9/88;C12N9/90;C12N15/09;C12P21/00 |
主分类号 |
C12P21/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
