发明名称 THERAPEUTIC AGENT FOR CANCER RESISTANT TO PROTEASE INHIBITOR
摘要 The present invention provides therapeutic agents for a cancer resistant to a protease inhibitor which comprises, as an active ingredient, a benzoyl compound represented by formula (I): [wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkyl, CONR7R8 (wherein R7 and R8, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like), or the like; R2 represents substituted or unsubstituted aryl or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R4 represents a hydrogen atom or the like; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like] or a pharmaceutically acceptable salt thereof as a heat shock protein 90 (Hsp90) family protein inhibitor, and the like.
申请公布号 US2011112099(A1) 申请公布日期 2011.05.12
申请号 US20080674230 申请日期 2008.08.21
申请人 KYOWA HAKKO KIRIN CO., LTD. 发明人 NAKASHIMA TAKAYUKI;SHIOTSU YUKIMASA
分类号 A61K31/535;A61K31/12;A61K31/445;A61K31/47;A61K31/4965;A61P35/00;A61P35/02 主分类号 A61K31/535
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