PROTEIN CROSSLINKING INHIBITOR AND USE THEREOF

摘要

Disclosed are: a ketone compound which is represented by general formula (1), (2) or (3) and has transglutaminase inhibitory activity; a protein crosslinking inhibitor which contains the compound; and a composition for prevention or treatment of diseases that are caused by crosslinking of proteins, said composition containing the compound or the protein crosslinking inhibitor. (In the formulae, R1 represents a substituted or unsubstituted aryl group or heterocyclic group; R2, R3 and R4 each represents a hydrogen atom; n represents 2; X represents a halogen atom; and R5 and R6 each independently represents a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl group, aryl group or aralkyl group. In this connection, R5 and R6 are not hydrogen atoms at the same time, and R5 and R6 may combine together to form a saturated or unsaturated, substituted or unsubstituted heterocyclic group that contains a nitrogen atom (N).)