| 摘要 |
<p>Method for preparing Gliclazide is disclosed, which comprises following steps: reacting p-Toluenesulfonylurea as raw material with hydrazine hydrate to obtain compound IV by condensation; then reacting compound IV with 1,2 -cyclopentane dicarboxylic anhydride to obtain compound II; finally, reducing compound II to obtain Gliclazide. The present method for preparing Gliclazide avoids the use of amino heterocyclic group, and fundamentally solves the oxidation trend of the raw materials. Intermediate compound II and its synthesis method are also disclosed.</p> |
