| 发明名称 |
Factor VIII Muteins with Reduced Immonugenicity |
| 摘要 |
The invention relates to modified Factor VIII molecules with reduced N-linked glycosylation and reduced immunogenicity. The invention also relates to methods of using modified Factor VIII molecules, for example, to treat patients afflicted with hemophilia.
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| 申请公布号 |
US2011112022(A1) |
申请公布日期 |
2011.05.12 |
| 申请号 |
US200913001360 |
申请日期 |
2009.06.25 |
| 申请人 |
BAYER HEALTHCARE LLC |
发明人 |
ASWAD FRED JULLIEN;HARKINS RICHARD;LIU HSIAO-LAI;MURPHY JOHN E.;WU FAYE;ZHU YING |
| 分类号 |
A61K38/37;A61K31/7088;C07H21/00;C07K14/755;C12N5/071;C12N15/63 |
主分类号 |
A61K38/37 |
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