Provided herein are methods of treating a subject with cancer comprising administering to the subject a death receptor agonist. Also provided herein are methods of screening a breast cancer cell for responsiveness to a DR5 agonist. Further provided herein are antibodies that selectively bind an N-terminal CARD of DDX3, a DDX3 lacking an N-terminal CARD, and an 80 kDa baculovirus IAP repeat (BIR).
申请公布号
WO2011057099(A2)
申请公布日期
2011.05.12
申请号
WO2010US55664
申请日期
2010.11.05
申请人
THE UAB RESEARCH FOUNDATION;BUCHSBAUM, DONALD J.;ZHOU, TONG;LOBUGLIO, ALBERT F.
发明人
BUCHSBAUM, DONALD J.;ZHOU, TONG;LOBUGLIO, ALBERT F.