发明名称 |
ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF HEXAHYDROINDENOPYRIDINE AND OCTAHYDROBENZOQUINOLINE |
摘要 |
The present invention relates to compounds defined by formula I, wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11 ß-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia. |
申请公布号 |
CA2778161(A1) |
申请公布日期 |
2011.05.12 |
申请号 |
CA20102778161 |
申请日期 |
2010.11.05 |
申请人 |
VITAE PHARMACEUTICALS, INC.;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
ECKHARDT, MATTHIAS;PETERS, STEFAN;NAR, HERBERT;HIMMELSBACH, FRANK;ZHUANG, LINGHANG |
分类号 |
C07D221/10;A61K31/473;A61K31/497;A61K31/498;A61K31/5377;A61P3/00;C07D401/06;C07D401/12;C07D401/14;C07D405/14;C07D417/06;C07D471/04;C07D498/04 |
主分类号 |
C07D221/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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