CHEMICAL MODIFICATION OF SMALL HAIRPIN RNAS FOR INHIBITION OF GENE EXPRESSION
摘要
Aspects of the present invention include the production and use of chemically modified RNAi agents (e.g., shRNAs) in gene silencing applications. The chemically modified RNAi agents disclosed herein have reduced immunostimulatory activity, increased serum stability, or both, as compared to a corresponding RNAi agent not having the chemical modification. Compositions containing chemically modified RNAi agents according to aspects of the present invention (including pharmaceutical compositions) and kits containing the same are also provided.
申请公布号
WO2011008730(A3)
申请公布日期
2011.05.12
申请号
WO2010US41782
申请日期
2010.07.13
申请人
SOMAGENICS INC.;INTEGRATED DNA TECHNOLOGIES;GE, QING;JOHNSTON, BRIAN H.;BEHLKE, MARK A.;ILVES, HEINI;DALLAS, ANNE
发明人
GE, QING;JOHNSTON, BRIAN H.;BEHLKE, MARK A.;ILVES, HEINI;DALLAS, ANNE