DIAGNOSTIC METHODS FOR DETERMINING PROGNOSIS OF NON-SMALL-CELL LUNG CANCER

摘要

Disclosed are methods for identifying early-stage non- small - cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery that chromosomal copy number gains at Chrl9, 34.7 Mb - 35.6 Mb can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with f luorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of this genetic locus, which includes the cyclin El gene.