| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for speedily and readily evaluating drugs having preventive or remedial effects on disorders caused by advanced glycation endproducts (AGEs) produced by the Maillard reaction progressing, in a living body by an in vivo evaluation system, including pharmacological evaluations of safety or the like, and to provide a screening method capable of finding drugs having superior inhibiting effects of the production of AGEs, high safety with respect to living bodies, and satisfactory dispositions using such a method. SOLUTION: In the drug evaluation method, it is evaluated as to whether a drug has preventive or remedial effects on disorders caused by high levels of blood sugar in a human body, and/or the degree of effects of the drug is evaluated, and the magnitude of remedial effects on a growth-inhibiting phenomenon of the drug to a growth-inhibiting phenomenon in a state of high levels of blood sugar exhibited by a larva of a holometabolous insect is measured. COPYRIGHT: (C)2011,JPO&INPIT
|
