CONTROLLED RELEASE PARTICLES AND METHOD FOR PREPARATION THEREOF

摘要

A process for preparing a particulate composition for controlled release of an active agent, the process comprising: forming a double emulsion comprising (i) an internal phase comprising droplets of a suspension in a first liquid of mesoporous silica particles and the active agent sorbed into the mesoporous silica particles; (ii) an intermediate dispersed phase within which the first liquid is dispersed comprising a second liquid; and an organic polymer or precursor thereof; and (iii) a continuous phase; and curing the polymer or precursor thereof to form microspheres comprising a coating of the polymer about the mesoporous silica particles.