发明名称 |
Detection of SHED CD31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling pathways |
摘要 |
The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. A method for detecting shed CD31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as CD31 and to the use of such a method as a diagnostic tool. The invention further provides methods for determining whether a candidate protein is part of a molecular complex. |
申请公布号 |
EP2318842(A1) |
申请公布日期 |
2011.05.11 |
申请号 |
EP20090772456 |
申请日期 |
2009.06.30 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
CALIGIURI, GIUSEPPINA;NICOLETTI, ANTONINO |
分类号 |
G01N33/68;C07K16/28;G01N33/543 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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