| 摘要 |
The invention comprises compounds of the formula <FORM:0978288/C1/1> (wherein R1 and R2 are alkyl radicals each of at most 4 carbon atoms and X, Y and Z are hydrogen or chlorine atoms, or alkoxy radicals of at most 4 carbon atoms, or two of them may represent a methylenedioxy radical, at least one of X, Y and Z being other than hydrogen) and their preparation by reacting nicotinic acid or a functional derivative thereof with the appropriately substituted phenylethylamine. Functional derivatives referred to are azides, esters, mixed anhydrides and halides, the last-named preferably being used as their hydrohalides. Examples are given. Amines of the formula <FORM:0978288/C1/2> are prepared by reduction of the corresponding nitriles, themselves prepared by alkylation of benzyl cyanides substituted in the nucleus by the required groups X, Y and Z. The substituted nicotinamides of the invention, which are stated to have a sedative, tranquilizing and neuroleptic action, may be made up into pharmaceutical compositions with suitable carriers. These may take the form of capsules, dragees, emulsions or tablets. |
