| 摘要 |
Benzenesulfonylureas of general formula (I): X - CO - - Y - phenylene - SO2 - NH - CO-NH-R' R = H, low alkyl or low phenylalkyl; R' = nortricyclyl or adamantyl; X = a) a phenylgroup carrying at random positions the substituents Z and Z' which may be equal or different. Z = H, halogen, low alkyl, alkenyl, alkoxy, alkenoxy, halogenalkoxy, alkoxyalkoxy, phenalkoxy, phenylalkyl, cycloalkoxy, phenyl, phenoxy, low acyl, benzoyl, trifluoromethyl, hydroxy, low acyloxy, -CN or -NO2; Z' = H, halogen, Low alkyl, alkoxy, alkoxyalkoxy, halogenalkoxy or acyloxy, hydroxy; b) a naphthylgroup possibly mono- or disubstituted with halogen, low alkyl, low alkoxy or hydroxyl; c) a tetrahydronaphthyl- or indanylgroup; d) a thiophenylgroup possibly mono- or disubstituted with low alkyl, phenylalkyl, alkoxy, alkoxyalkoxy, alkenoxy, phenylalkoxy or halogenalkoxy, aryl or halogen; e) a tetramethylene- or trimethylenetenylgroup; Y = a hydrocarbon group with 1-4C-atoms The phenylenegroup in the formula is preferably not substituted, but may be substituted once or more times with low alkyl, halogen, or low alkoxy; the group can connect the other parts of the molecule in ortho-,meta- or preferably para position. The new compounds have a very strong blood sugar lowering activity with very good tolerance and may be used in the treatment of diabetus mellitus. |
